Genetics of Allergic Diseases and Acne Vulgaris in the Singapore Population: Validation and Functional Characterization of Candidates
10 February 2025
Main Applicant – A/Prof Chew Fook Tim, Department of Biological Science, National University of Singapore
Allergic diseases including asthma, allergic rhinitis (AR), and atopic dermatitis (AD) are common disorders with increasing prevalence over recent decades in the Singapore population (Lim et al., 2022; Wong et al., 2023; Wong et al., 2022).
Acne vulgaris is a common inflammatory skin condition with an estimated prevalence of 53.8% in the Singapore population (Heng, Say, Sio, Ng, & Chew, 2021). Asthma carries a significant morbidity and mortality burden, adversely affecting the quality of living and causing premature death, rendering a global health issue which cannot be ignored. Although AR, AD, and acne are not life-threatening, these disorders also affect the self-confidence, quality of life, and mental well-being of the patients. Both genetics and environmental factors are important contributors to the pathogenesis of these disorders.
Understanding the pathophysiology of these common disorders provide opportunities to develop affordable and effective strategies for the prevention, management, and treatment of these disorders.